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KMID : 1059520130570050634
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Journal of the Korean Chemical Society
2013 Volume.57 No. 5 p.634 ~ p.639
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Preparation of Gold Coated Liposomes for CT Contrast Medium
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Wee Tae-In
Jeon Ye-Won
Cho Young-Jae
Cho Sung-Keun
Ha Jeung
Lee Jeong-Won
Cho Sun-Hang
Han Hee-Dong
Shin Byung-Cheol
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Abstract
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The use of medical imaging has been increased for diagnosis of cancer or vessel disease. Among the medical imaging, computed tomography (CT) is one of the popular methods, however, which should need administration of contrast medium. Therefore, we developed gold coated liposomes (GCL) as a contrast medium. To coat gold on the liposomal surface, positive charged liposomes was prepared and then negative Au- can coat on the liposomal surface by electronic interaction. The size of GCL was 154.8 ± 9.2 nm and surface charge was 27 ± 3.2 mV, respectively. The morphology of GCL was confirmed by electron microscopy (SEM) and transmission electron microscopy (TEM). The coating efficiency of gold was 18%. Chemical procedure for gold coating on liposomal surface was not toxic for cell cytotoxicity by MTT assay. Finally, we demonstrated attractive CT image for GCL. Taken together, the GCL would be useful for various vessel related disease as a contrast medium.
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KEYWORD
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Gold, Liposomes, Contrast medium, CT
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